抗體細胞連結技術(ACC)

The antibody-cell conjugation(ACC) can be divided into three elements. The click chemistry is involved in the conjugation process that clicks antibodies to the live cells. And the aptamer we use in ACC is functional as a T cell engager, one arm engages with T cell and the other arm can selectively grab tumor cell which subsequently enhances potency through immune activation receptors activating NFAT signaling pathway. The covalent bonding of aptamer sustains the high affinity of antibody-conjugated effector cells toward the tumor cells.