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γδ2 T 細胞

育世博生物科技股份有限公司的γδ2 T細胞項目利用γδ2 T細胞的獨特性,開發用於治療癌症的新穎現成型細胞療法。γδ2 T細胞具有先天和後天免疫系統的特性,是開發細胞療法的理想基底。此種細胞類型可以直接識別並攻擊癌細胞,招集和活化其他免疫因子及免疫細胞至病灶,來協調廣泛的的抗癌免疫反應。γδ2 T細胞也被證實能移動至不同的組織,作為更準確標靶一些特定癌症類型標靶治療的理想選擇。
Advantages of Acepodia’s γδ2 T Cell Technology

Advantages of Acepodia’s γδ2 T Cell Technology

Acepodia has developed a unique γδ2 T cells that are enriched to provide the added benefits of NK functions through its proprietary selection and expansion technology. The γδ2 T cells express high level of activating receptors such as CD2 and NKG2D and low level of inhibitory receptors, enhancing potency to directly kill the tumor cells and indirectly activate other immune factors against the malignancy. Unlike traditional T cell therapies, γδ2 T cells can be administered off-the-shelf and do not need to be tailored for each individual patient, allowing for a streamlined manufacturing process and broader potential use. While an attractive candidate for cell therapies, gamma delta2 T cells only represent a small fraction of circulating T cells which has greatly limited their use in the past.
Evaluating the Promise of γδ2 T Cells

Evaluating the Promise of γδ2 T Cells

Acepodia is overcoming the limited nature of γδ2 T cells by developing a proprietary allogeneic γδ2 T cell production that represents a consistent and scalable source of γδ2 T cells. Using its integrated approach, Acepodia is enhancing its γδ2 T cells for the development of therapies that can complement its other cell therapy programs.
Manufacturing & Off-the-shelf Scalability

Manufacturing & Off-the-shelf Scalability

Current autologous cell therapies that are generated from a patient’s own cells require weeks to prepare. Unlike most αβT cells, γδ2 T cells can be given off-the-shelf, meaning that they do not need to be tailored to an individual patient which allows for a streamlined manufacturing process and increased scalability. Moreover, γδ2 T cells can be cryopreserved so that they are ready when patients need them. Cumulatively, these benefits translate to lower costs and greater availability for patients.
Increased Tolerability

Increased Tolerability

γδ2 T cell therapies may have a reduced risk for dangerous and potentially life-threatening reactions such as graft-versus-host disease (GvHD) or cytokine storm syndrome.

Guiding γδ2 T Cells Directly to Tumor Sites: ACC

Currently available cell therapies also present challenges in effectively engaging cancer cells due to immunosuppression caused by the tumor microenvironment. By uniting its potent γδ2 T cells with well-established, as well as proprietary and novel tumor-targeting mechanisms, Acepodia’s cell therapy candidates are designed to target cancer cells and overcome tumor defenses to deliver their potent, cancer-killing cellular payload.



ACC-γδ2 T

CD20標靶、ACC-γδ2 T細胞療法
Phase I ​
抗EGFR、ACC-γδ2 T細胞療法
Preclinical ​
抗PD-L1、ACC-γδ2 T細胞療法
Discovery ​
We have collaborated with biopharmaceutical partners and academic institutes worldwide.